5. Zorak (Space Ghost: Coast to Coast, Cartoon Planet, The Brak Show) [RIP]
4. Lee Russell (Vice Principals)
3. Jerri Blank (Strangers With Candy)
2. Rusty Venture (The Venture Bros.)
1. Saul Goodman (Breaking Bad, Better Call Saul)
Couldn't choose one character from the Wire or Steven Universe. Al Swearengen is a close 6th.