I'm personally good with the awfulness to date (although the half-assed Twin Peak wedding has me gritting my teeth every time I listen to it), but two friends have two separate ones they can't handle.
Introducing one friend to the F Plus: after one of the recipe ones, the mistake was made of queuing up the anti-vac/unschooling episode. This friend being a new mother, someone with anti-vac relatives, and a teacher. It was like the perfect storm of everything nightmarish for her. I don't think she made it halfway.
Another friend who's a regular listener won't listen to one with the glasses' fetishists. She doesn't wear glasses at all, but has blind grandparents and one side of her family with serious eyesight degradation leading to blindness. The thought of someone fetishizing something she's so familiar with is too much, even with the promise of STOG singing.
I, like a couple other people in the thread, definitely had to tap out in a couple Lou Reads, though, which keeps me humble. Humble about listening to gross podcasts.